ABSTRACT
<p><b>OBJECTIVE</b>To identify the predictors of the positive results of transrectal ultrasound (TRUS)-guided biopsy for prostate cancer.</p><p><b>METHODS</b>We performed univariate and multivariate logistic regression analyses on the relevant data on 385 male patients that underwent TRUS-guided biopsy for prostate cancer, including such potential predictors as age, body mass index (BMI), symptoms, results of digital rectal examination (DRE), tPSA, fPSA, free/total PSA ratio (f/tPSA), prostate volume (PV), and PSA density (PSAD) for identification of the risk factors related to the positive rate of biopsy. Then we constructed a scoring system as a tool for predicting prostate cancer in repeat biopsies and determined the sensitivity of the system by calculating the false positive rate using the receiver operating characteristic curve.</p><p><b>RESULTS</b>Among the 385 patients, 139 (36.1%) were diagnosed with prostate cancer. On multivariate analysis, age (P < 0.01), DRE (P < 0.01), tPSA (P < 0.01), fPSA (P < 0.01), f/tPSA (P < 0.01), PV (P < 0.01), and PSAD (P < 0.01) were all significant predictors of prostate cancer. Multivariate logistic regression analysis showed age, tPSA, f/tPSA, PV, and PSAD to be independent predictors, with ORs and 95% CIs of 1.07 (1.05-1.16), 1.05 (1.02-1.15), 0.97 (0.86-0.99), 0.98 (0.87-0.96), and 1.79 (1.48-2.06), respectively. Moreover, patients with the risk score of 3-5 had a significantly higher rate of prostate cancer than those with 0-2 (64% vs 11%, P < 0.001).</p><p><b>CONCLUSION</b>The scoring system on the key predictors of prostate cancer can help urologists to identify the men in need of prostatic biopsy.</p>
Subject(s)
Aged , Humans , Male , Middle Aged , Digital Rectal Examination , Image-Guided Biopsy , Methods , Logistic Models , Prostate , Pathology , Prostate-Specific Antigen , Prostatic Neoplasms , Chemistry , Pathology , ROC Curve , Risk Factors , Ultrasonography, Interventional , MethodsABSTRACT
<p><b>OBJECTIVE</b>To evaluate the abnormal state of liver function and plasma lipid levels of obese schoolchildren who were screened by weight-for-height criterion and new body mass index criterion respectively.</p><p><b>METHODS</b>280 obese children were screened by weight-for-height criterion and 125 obese children were screened by body mass index criterion in a routine school check-up program. All of the latter subjects was included in the former one. One obese child and 1 non-obese child were matched for gender and age. 14 items related to liver functions and plasma lipids were measured.</p><p><b>RESULTS</b>Of the abnormal items,7 items in 125 obese children screened by new BMI criterion and 5 items in 155 "obese children" excluded by BMI criterion, were significantly higher than those children among controlled group. The abnormal rates were 10.4%-22.9% in the former and 3.2%-13.0% in the latter.</p><p><b>CONCLUSIONS</b>The new BMI criterion seemed to be more stringent than weight-for-height. Less than a half of the obese children screened by weight-for-height were taken on obese children by new BMI criterion. The overweight children who were screened by BMI criterion also had abnormal liver functions and plasma lipids.</p>